The nuclear receptor 4A family members: mediators in human disease and autophagy

The nuclear receptor 4A family members: mediators in human disease and autophagy

Blog Article

Abstract The Nuclear receptor 4A (NR4A) subfamily, which belongs to the nuclear receptor (NR) superfamily, has three members: NR4A1 (Nur77), NR4A2 (Nurr1) and NR4A3 (Nor1).They are gene kaiser copy stands regulators with broad involvement in various signaling pathways and human disease responses, including autophagy.Here, we provide a concise overview of the current understanding of the role of the NR4A subfamily members in human diseases and review the research into their regulation of cell autophagy.A deeper understanding of these mechanisms has potential to improve drug development processes and 5.11 flex shotgun ammo pouch disease therapy.